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Antiestrogens: mechanisms and actions in target cells. In hyperthyroid individuals, ATP turnover rate is faster than in normal individuals, whereas in hypothyroid individuals, ATP turnover is slower The fraction of strong binding myosin in OVX muscle is 0. Effect of oestrogen on myofibre size and myosin expression in growing rats. Just as in experimental animal models, myosin isoform mRNA and protein composition can be very different between men and women. Estrogen The relationship between estrogen and skeletal muscle function and recovery has been analyzed for decades. These anabolic effects of testosterone are well characterized and provide the catalysts for further investigation of the response of muscle fiber-type composition to testosterone deficiency and supplementation in males and females.

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Analysis of contractile function in OVX mice reveals a significant decrease in maximal isometric tetanic force from sham levels mN to mN 67 ,

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Importantly, MyHC isoform expression closely correlates with fiber-type morphology and enzymatic make-up. J Muscle Res Cell Motil 18 : —, Contractility Studies on chemically skinned human fibers reveal that MyHC isoform composition is the key determinant of muscle fiber contractile velocity and rate of force development 11 , In the following section, we present findings on the effects of thyroid hormone, estrogen, and testosterone on contractility, fiber type, and the differences that occur between the sexes.

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